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CTEC Projects :::: Skin and Wound Healing

Wound healing associated with aging, diabetes, vascular compromise, and skin cancers remains major problems and presents a significant unmet medical need. Several "skin equivalent" models have been developed that allow in vitro formation of functional multicellular tissue systems that reproduce the biological environment and signaling of normal keratinocytes and even dermis. These models present a valuable opportunity for drug and cosmetic screening, and for fabrication of live-cell dressings or grafts for wound repair. Protocol pathways for characterization of these constructs using state-of-the-art image analysis of histology, 3D imaging as well as gene expression, proteomics, and flow cytometry analyses are being collaboratively integrated, with an eye toward translational research projects and eventually clinical trials. Wound healing represents a large and growing market, as does the opportunity for new drug and "cosmeceutical" product screening. CTEC is actively developing new technologies and projects to meet this market need.

Project #23. Convect-A-Med: Development & Prototyping of a
Mechano-active Drug Delivery and Moisture Absorbing Wound Dressing. Investigators: M. Knothe-Tate, E. Maytin. For project details, click here.

Project #24. Optimizing Engineered Skin Substitute (ESS) using Autogenous Endothelial Cells and MSCs. Investigators: S Boyce, A Caplan, G Muschler. For project details, click here.

Project #25. Rapid Intra-operative Processing and Transplantation of Bone Marrow-Derived Cells for Enhanced Wound Repair. Investigators: G Muschler, S Boyce, M Zborowski. For project details, click here.

Project #26. Culture Expanded Human MSCs for Large-Area Wounds. Investigators: A Caplan, S Boyce, G Muschler. For project details, click here.

Project #27. Biologically Active Scaffolds for Scarless Healing. Investigators: E Alsberg, S Boyce. For project details, click here.

Project #28. Bone Marrow Stromal Cell Therapy for Enhancement of Nerve Regeneration and Neuroprotection.  Investigators: M Siemionow, G Muschler, A Caplan. For project details, click here.

Project #29. Enhanced Second Generation Wound Patch for Nitric Oxide Delivery.  Investigator: D Smith. For project details, click here.

Project #30. Customized Matrix for Skin Tissue Engineering.  Investigators: J Fulton. For project details, click here.

Project #31. Matrices for Skin and Muscle Tissue Engineering.  Investigators: L Liu, J Fulton, W Landis. For project details, click here.

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